Sweet taste loss in myasthenia gravis: more than a coincidence?

Détails

Ressource 1Télécharger: BIB_97361904F0E3.P001.pdf (326.27 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_97361904F0E3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Institution
Titre
Sweet taste loss in myasthenia gravis: more than a coincidence?
Périodique
Orphanet Journal of Rare Diseases
Auteur(s)
Chabwine J.N., Tschirren M.V., Zekeridou A., Landis B.N., Kuntzer T.
ISSN
1750-1172 (Electronic)
ISSN-L
1750-1172
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
50-53
Langue
anglais
Notes
Publication types: Letter Publication Status: epublish
Résumé
Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas lpr/ (MRL/lpr) transgenic mice with autoimmune disease.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/07/2014 11:28
Dernière modification de la notice
20/08/2019 14:59
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