Sweet taste loss in myasthenia gravis: more than a coincidence?

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_97361904F0E3
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Sweet taste loss in myasthenia gravis: more than a coincidence?
Journal
Orphanet Journal of Rare Diseases
Author(s)
Chabwine J.N., Tschirren M.V., Zekeridou A., Landis B.N., Kuntzer T.
ISSN
1750-1172 (Electronic)
ISSN-L
1750-1172
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
9
Number
1
Pages
50-53
Language
english
Notes
Publication types: Letter Publication Status: epublish
Abstract
Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas lpr/ (MRL/lpr) transgenic mice with autoimmune disease.
Pubmed
Web of science
Open Access
Yes
Create date
30/07/2014 11:28
Last modification date
20/08/2019 14:59
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