Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_9700E363D9A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
Périodique
Nature
Auteur(s)
Jacquemont S., Reymond A., Zufferey F., Harewood L., Walters R.G., Kutalik Z., Martinet D., Shen Y., Valsesia A., Beckmann N.D., Thorleifsson G., Belfiore M., Bouquillon S., Campion D., de Leeuw N., de Vries B.B., Esko T., Fernandez B.A., Fernández-Aranda F., Fernández-Real J.M., Gratacòs M., Guilmatre A., Hoyer J., Jarvelin M.R., Kooy R.F., Kurg A., Le Caignec C., Männik K., Platt O.S., Sanlaville D., Van Haelst M.M., Villatoro Gomez S., Walha F., Wu B.L., Yu Y., Aboura A., Addor M.C., Alembik Y., Antonarakis S.E., Arveiler B., Barth M., Bednarek N., Béna F., Bergmann S., Beri M., Bernardini L., Blaumeiser B., Bonneau D., Bottani A., Boute O., Brunner H.G., Cailley D., Callier P., Chiesa J., Chrast J., Coin L., Coutton C., Cuisset J.M., Cuvellier J.C., David A., de Freminville B., Delobel B., Delrue M.A., Demeer B., Descamps D., Didelot G., Dieterich K., Disciglio V., Doco-Fenzy M., Drunat S., Duban-Bedu B., Dubourg C., El-Sayed Moustafa J.S., Elliott P., Faas B.H., Faivre L., Faudet A., Fellmann F., Ferrarini A., Fisher R., Flori E., Forer L., Gaillard D., Gerard M., Gieger C., Gimelli S., Gimelli G., Grabe H.J., Guichet A., Guillin O., Hartikainen A.L., Heron D., Hippolyte L., Holder M., Homuth G., Isidor B., Jaillard S., Jaros Z., Jiménez-Murcia S., Helas G.J., Jonveaux P., Kaksonen S., Keren B., Kloss-Brandstätter A., Knoers N.V., Koolen D.A., Kroisel P.M., Kronenberg F., Labalme A., Landais E., Lapi E., Layet V., Legallic S., Leheup B., Leube B., Lewis S., Lucas J., MacDermot K.D., Magnusson P., Marshall C., Mathieu-Dramard M., McCarthy M.I., Meitinger T., Mencarelli M.A., Merla G., Moerman A., Mooser V., Morice-Picard F., Mucciolo M., Nauck M., Ndiaye N.C., Nordgren A., Pasquier L., Petit F., Pfundt R., Plessis G., Rajcan-Separovic E., Ramelli G.P., Rauch A., Ravazzolo R., Reis A., Renieri A., Richart C., Ried J.S., Rieubland C., Roberts W., Roetzer K.M., Rooryck C., Rossi M., Saemundsen E., Satre V., Schurmann C., Sigurdsson E., Stavropoulos D.J., Stefansson H., Tengström C., Thorsteinsdóttir U., Tinahones F.J., Touraine R., Vallée L., van Binsbergen E., Van der Aa N., Vincent-Delorme C., Visvikis-Siest S., Vollenweider P., Völzke H., Vulto-van Silfhout A.T., Waeber G., Wallgren-Pettersson C., Witwicki R.M., Zwolinksi S., Andrieux J., Estivill X., Gusella J.F., Gustafsson O., Metspalu A., Scherer S.W., Stefansson K., Blakemore A.I., Beckmann J.S., Froguel P.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
2011
Volume
478
Numéro
7367
Pages
97-102
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Both obesity and being underweight have been associated with increased mortality. Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m(2) in adults and ≤ -2 standard deviations from the mean in children, is the main sign of a series of heterogeneous clinical conditions including failure to thrive, feeding and eating disorder and/or anorexia nervosa. In contrast to obesity, few genetic variants underlying these clinical conditions have been reported. We previously showed that hemizygosity of a ∼600-kilobase (kb) region on the short arm of chromosome 16 causes a highly penetrant form of obesity that is often associated with hyperphagia and intellectual disabilities. Here we show that the corresponding reciprocal duplication is associated with being underweight. We identified 138 duplication carriers (including 132 novel cases and 108 unrelated carriers) from individuals clinically referred for developmental or intellectual disabilities (DD/ID) or psychiatric disorders, or recruited from population-based cohorts. These carriers show significantly reduced postnatal weight and BMI. Half of the boys younger than five years are underweight with a probable diagnosis of failure to thrive, whereas adult duplication carriers have an 8.3-fold increased risk of being clinically underweight. We observe a trend towards increased severity in males, as well as a depletion of male carriers among non-medically ascertained cases. These features are associated with an unusually high frequency of selective and restrictive eating behaviours and a significant reduction in head circumference. Each of the observed phenotypes is the converse of one reported in carriers of deletions at this locus. The phenotypes correlate with changes in transcript levels for genes mapping within the duplication but not in flanking regions. The reciprocal impact of these 16p11.2 copy-number variants indicates that severe obesity and being underweight could have mirror aetiologies, possibly through contrasting effects on energy balance.
Pubmed
Web of science
Création de la notice
28/09/2011 14:13
Dernière modification de la notice
20/08/2019 15:59
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