Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.

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Etat: Public
Version: Final published version
Licence: Tous droits réservés
ID Serval
serval:BIB_966E09A9670E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.
Périodique
NMR in biomedicine
Auteur⸱e⸱s
Lanz B., Abaei A., Braissant O., Choi I.Y., Cudalbu C., Henry P.G., Gruetter R., Kara F., Kantarci K., Lee P., Lutz N.W., Marjańska M., Mlynárik V., Rasche V., Xin L., Valette J.
Collaborateur⸱rice⸱s
Experts' Working Group on Magnetic resonance spectroscopy in the rodent brain, Experts' Working Group on Magnetic resonance spectroscopy in the rodent brain
Contributeur⸱rice⸱s
Behar K., Boumezbeur F., Deelchand D.K., Dreher W., Klaunberg B.A., Ligneul C., Lindquist D.M., Öz G., Tkáč I., Williams S.R.
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Statut éditorial
Publié
Date de publication
31/05/2021
Peer-reviewed
Oui
Volume
34
Numéro
5
Pages
e4325
Langue
anglais
Notes
Publication types: Journal Article
Résumé
In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical <sup>1</sup> H, <sup>31</sup> P and <sup>13</sup> C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts' consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical compared with clinical MRS studies is presented, as well as the additional biochemical information that can be obtained in animal models in terms of metabolite concentrations and metabolic flux measurements. The properties of high-field preclinical MRS and the technical limitations are also described.
Mots-clé
anesthesia, brain metabolism, consensus review, dynamic MRS, neurochemical profile, preclinical MRS
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/02/2021 9:05
Dernière modification de la notice
27/05/2023 5:50
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