Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.

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State: Public
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Serval ID
serval:BIB_966E09A9670E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.
Journal
NMR in biomedicine
Author(s)
Lanz B., Abaei A., Braissant O., Choi I.Y., Cudalbu C., Henry P.G., Gruetter R., Kara F., Kantarci K., Lee P., Lutz N.W., Marjańska M., Mlynárik V., Rasche V., Xin L., Valette J.
Working group(s)
Experts' Working Group on Magnetic resonance spectroscopy in the rodent brain, Experts' Working Group on Magnetic resonance spectroscopy in the rodent brain
Contributor(s)
Behar K., Boumezbeur F., Deelchand D.K., Dreher W., Klaunberg B.A., Ligneul C., Lindquist D.M., Öz G., Tkáč I., Williams S.R.
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Publication state
Published
Issued date
30/04/2020
Peer-reviewed
Oui
Pages
e4325
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical <sup>1</sup> H, <sup>31</sup> P and <sup>13</sup> C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts' consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical compared with clinical MRS studies is presented, as well as the additional biochemical information that can be obtained in animal models in terms of metabolite concentrations and metabolic flux measurements. The properties of high-field preclinical MRS and the technical limitations are also described.
Keywords
anesthesia, brain metabolism, consensus review, dynamic MRS, neurochemical profile, preclinical MRS
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2021 10:05
Last modification date
20/07/2022 6:39
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