Safe and effective variability-a criterion for dose individualization.

Détails

ID Serval
serval:BIB_961E4C3BFB2C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Safe and effective variability-a criterion for dose individualization.
Périodique
Therapeutic Drug Monitoring
Auteur(s)
Holford N.H., Buclin T.
ISSN
1536-3694 (Electronic)
ISSN-L
0163-4356
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
34
Numéro
5
Pages
565-568
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND: : A primary goal of clinical pharmacology is to understand the factors that determine the dose-effect relationship and to use this knowledge to individualize drug dose.
METHODS: : A principle-based criterion is proposed for deciding among alternative individualization methods.
RESULTS: : Safe and effective variability defines the maximum acceptable population variability in drug concentration around the population average.
CONCLUSIONS: : A decision on whether patient covariates alone are sufficient, or whether therapeutic drug monitoring in combination with target concentration intervention is needed, can be made by comparing the remaining population variability after a particular dosing method with the safe and effective variability.
Pubmed
Web of science
Création de la notice
18/10/2012 17:05
Dernière modification de la notice
20/08/2019 14:58
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