Safe and effective variability-a criterion for dose individualization.

Details

Serval ID
serval:BIB_961E4C3BFB2C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Safe and effective variability-a criterion for dose individualization.
Journal
Therapeutic Drug Monitoring
Author(s)
Holford N.H., Buclin T.
ISSN
1536-3694 (Electronic)
ISSN-L
0163-4356
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
34
Number
5
Pages
565-568
Language
english
Notes
Publication types: Journal Article
Abstract
BACKGROUND: : A primary goal of clinical pharmacology is to understand the factors that determine the dose-effect relationship and to use this knowledge to individualize drug dose.
METHODS: : A principle-based criterion is proposed for deciding among alternative individualization methods.
RESULTS: : Safe and effective variability defines the maximum acceptable population variability in drug concentration around the population average.
CONCLUSIONS: : A decision on whether patient covariates alone are sufficient, or whether therapeutic drug monitoring in combination with target concentration intervention is needed, can be made by comparing the remaining population variability after a particular dosing method with the safe and effective variability.
Pubmed
Web of science
Create date
18/10/2012 17:05
Last modification date
20/08/2019 14:58
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