Efavirenz intoxication due to slow hepatic metabolism
Détails
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_94D5173C4402
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Efavirenz intoxication due to slow hepatic metabolism
Périodique
Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Statut éditorial
Publié
Date de publication
2005
Volume
40
Numéro
3
Pages
e22-e23
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.
Mots-clé
Anti-HIV Agents/adverse effects, Anti-HIV Agents/blood, Anti-HIV Agents/metabolism, Aryl Hydrocarbon Hydroxylases/genetics, HIV Infections/drug therapy, Liver/enzymology, Oxazines/adverse effects, Oxazines/blood, Oxazines/metabolism, Oxidoreductases, N-Demethylating/genetics, Psychoses, Substance-Induced/diagnosis
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/07/2018 9:00
Dernière modification de la notice
14/02/2022 7:56
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