Efavirenz intoxication due to slow hepatic metabolism

Details

Ressource 1Download: serval:BIB_94D5173C4402.P001 (60.88 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_94D5173C4402
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Efavirenz intoxication due to slow hepatic metabolism
Journal
Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America
Author(s)
Hasse B., Günthard H.F., Bleiber G., Krause M.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Publication state
Published
Issued date
2005
Volume
40
Number
3
Pages
e22-e23
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.
Keywords
Anti-HIV Agents/adverse effects, Anti-HIV Agents/blood, Anti-HIV Agents/metabolism, Aryl Hydrocarbon Hydroxylases/genetics, HIV Infections/drug therapy, Liver/enzymology, Oxazines/adverse effects, Oxazines/blood, Oxazines/metabolism, Oxidoreductases, N-Demethylating/genetics, Psychoses, Substance-Induced/diagnosis
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2018 10:00
Last modification date
25/09/2019 7:10
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