Inflammatory bowel perforation during immune restoration after one year of antiretroviral and antituberculous therapy in an HIV-1-infected patient: report of a case

Détails

ID Serval
serval:BIB_935FB9C48AF9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Inflammatory bowel perforation during immune restoration after one year of antiretroviral and antituberculous therapy in an HIV-1-infected patient: report of a case
Périodique
Diseases of the Colon and Rectum
Auteur(s)
Guex  A. C., Bucher  H. C., Demartines  N., Fluckiger  U., Battegay  M.
ISSN
0012-3706 (Print)
Statut éditorial
Publié
Date de publication
07/2002
Volume
45
Numéro
7
Pages
977-8
Notes
Case Reports
Journal Article --- Old month value: Jul
Résumé
PURPOSE: This article reports an unusual presentation of bowel perforation. METHODS: We report the case of a 30-year-old HIV-infected male who suffered from an advanced state of CD4 cell depletion (29 CD4 cells per 106/l). Abdominal pain and diarrhea led to further examinations. RESULTS: Colonoscopy revealed a severe tuberculous ileocecal inflammation. Tuberculosis and HIV infection were treated. The patient's response to antiretroviral therapy was excellent. After 11 months of potent antiretroviral treatment and 12 months of antituberculous therapy he suffered from acute abdominal pain with fever and ileus. Laparotomy revealed two intestinal perforations of the jejunum and inflammation of the whole ileocecal region. CONCLUSION: Immunopathologic reactions caused by immune restoration are novel presentations of highly active antiretroviral treatment as shown here. The presented patient is an unusual case with a very late onset of inflammatory response, which led to intestinal perforation.
Mots-clé
AIDS-Related Opportunistic Infections/*drug therapy/*immunology Adult Antiretroviral Therapy, Highly Active/*adverse effects Antitubercular Agents/*adverse effects HIV Infections/*drug therapy/*immunology Hiv-1 Humans Inflammation/etiology Intestinal Perforation/*etiology Jejunal Diseases/*etiology Male Tuberculosis, Gastrointestinal/drug therapy/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 9:53
Dernière modification de la notice
20/08/2019 15:56
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