Inflammatory bowel perforation during immune restoration after one year of antiretroviral and antituberculous therapy in an HIV-1-infected patient: report of a case

Details

Serval ID
serval:BIB_935FB9C48AF9
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Inflammatory bowel perforation during immune restoration after one year of antiretroviral and antituberculous therapy in an HIV-1-infected patient: report of a case
Journal
Diseases of the Colon and Rectum
Author(s)
Guex  A. C., Bucher  H. C., Demartines  N., Fluckiger  U., Battegay  M.
ISSN
0012-3706 (Print)
Publication state
Published
Issued date
07/2002
Volume
45
Number
7
Pages
977-8
Notes
Case Reports
Journal Article --- Old month value: Jul
Abstract
PURPOSE: This article reports an unusual presentation of bowel perforation. METHODS: We report the case of a 30-year-old HIV-infected male who suffered from an advanced state of CD4 cell depletion (29 CD4 cells per 106/l). Abdominal pain and diarrhea led to further examinations. RESULTS: Colonoscopy revealed a severe tuberculous ileocecal inflammation. Tuberculosis and HIV infection were treated. The patient's response to antiretroviral therapy was excellent. After 11 months of potent antiretroviral treatment and 12 months of antituberculous therapy he suffered from acute abdominal pain with fever and ileus. Laparotomy revealed two intestinal perforations of the jejunum and inflammation of the whole ileocecal region. CONCLUSION: Immunopathologic reactions caused by immune restoration are novel presentations of highly active antiretroviral treatment as shown here. The presented patient is an unusual case with a very late onset of inflammatory response, which led to intestinal perforation.
Keywords
AIDS-Related Opportunistic Infections/*drug therapy/*immunology Adult Antiretroviral Therapy, Highly Active/*adverse effects Antitubercular Agents/*adverse effects HIV Infections/*drug therapy/*immunology Hiv-1 Humans Inflammation/etiology Intestinal Perforation/*etiology Jejunal Diseases/*etiology Male Tuberculosis, Gastrointestinal/drug therapy/immunology
Pubmed
Web of science
Create date
28/01/2008 9:53
Last modification date
20/08/2019 15:56
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