Proximal tubular function and salt sensitivity.

Détails

ID Serval
serval:BIB_91F218D6F5BC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Proximal tubular function and salt sensitivity.
Périodique
Current Hypertension Reports
Auteur(s)
Burnier M., Bochud M., Maillard M.
ISSN
1522-6417
Statut éditorial
Publié
Date de publication
04/2006
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
8-15
Langue
anglais
Notes
Journal Article Review --- Old month value: Apr
Résumé
Blood pressure response to changes in dietary salt intake is highly variable among individuals. This heterogeneity results from the combined effects of genetic and environmental determinants. In recent years, considerable progress has been made in our understanding of the pathogenic mechanisms leading to the development of salt-sensitive hypertension. Much information has come from the investigation of rare monogenic forms of salt-sensitive hypertension, which has focused attention on alterations of renal sodium handling occurring essentially in the distal nephron. In this paper, we review the experimental, clinical, genetic, and epidemiologic evidence suggesting that proximal tubular function is also an important determinant of the blood pressure response to salt, which deserves greater attention.
Mots-clé
Animals, Blood Pressure/physiology, Humans, Hypertension/metabolism, Hypertension/physiopathology, Kidney Tubules, Proximal/metabolism, Kidney Tubules, Proximal/physiopathology, Risk Factors, Sodium Chloride/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 13:59
Dernière modification de la notice
20/08/2019 15:55
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