Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_91C58DA1DCD4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology.
Périodique
Trends in neurosciences
Auteur⸱e⸱s
Saura C.A., Cardinaux J.R.
ISSN
1878-108X (Electronic)
ISSN-L
0166-2236
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
40
Numéro
12
Pages
720-733
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The brain has the ability to sense, coordinate, and respond to environmental changes through biological processes involving activity-dependent gene expression. cAMP-response element binding protein (CREB)-regulated transcription coactivators (CRTCs) have recently emerged as novel transcriptional regulators of essential biological functions, while their deregulation is linked to age-related human diseases. In the brain, CRTCs are unique signaling factors that act as sensors and integrators of hormonal, metabolic, and neural signals contributing to brain plasticity and brain-body communication. In this review, we focus on the regulatory mechanisms and functions of CRTCs in brain metabolism, lifespan, circadian rhythm, and synaptic mechanisms underlying memory and emotion. We also discuss how CRTCs deregulation in cognitive and emotional disorders may provide the basis for potential clinical and therapeutic applications in neurodegenerative and psychiatric diseases.

Mots-clé
Animals, Brain/metabolism, Brain/pathology, Cyclic AMP Response Element-Binding Protein/metabolism, Humans, Transcription Factors/metabolism, CREB, major depression, memory, neurodegeneration, synaptic plasticity
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/11/2017 16:15
Dernière modification de la notice
20/08/2019 14:54
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