Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_91C58DA1DCD4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology.
Journal
Trends in neurosciences
Author(s)
Saura C.A., Cardinaux J.R.
ISSN
1878-108X (Electronic)
ISSN-L
0166-2236
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
40
Number
12
Pages
720-733
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The brain has the ability to sense, coordinate, and respond to environmental changes through biological processes involving activity-dependent gene expression. cAMP-response element binding protein (CREB)-regulated transcription coactivators (CRTCs) have recently emerged as novel transcriptional regulators of essential biological functions, while their deregulation is linked to age-related human diseases. In the brain, CRTCs are unique signaling factors that act as sensors and integrators of hormonal, metabolic, and neural signals contributing to brain plasticity and brain-body communication. In this review, we focus on the regulatory mechanisms and functions of CRTCs in brain metabolism, lifespan, circadian rhythm, and synaptic mechanisms underlying memory and emotion. We also discuss how CRTCs deregulation in cognitive and emotional disorders may provide the basis for potential clinical and therapeutic applications in neurodegenerative and psychiatric diseases.

Keywords
Animals, Brain/metabolism, Brain/pathology, Cyclic AMP Response Element-Binding Protein/metabolism, Humans, Transcription Factors/metabolism, CREB, major depression, memory, neurodegeneration, synaptic plasticity
Pubmed
Web of science
Open Access
Yes
Create date
07/11/2017 16:15
Last modification date
20/08/2019 14:54
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