Isolation and characterization of major histocompatibility complex (MHC) class II B genes in the Barn owl (Aves: Tyto alba)

Détails

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ID Serval
serval:BIB_8EED7062E209
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Isolation and characterization of major histocompatibility complex (MHC) class II B genes in the Barn owl (Aves: Tyto alba)
Périodique
Immunogenetics
Auteur⸱e⸱s
Burri R., Niculita-Hirzel Hélène, Roulin A., Fumagalli L.
ISSN
0093-7711
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
60
Numéro
9
Pages
543-550
Langue
anglais
Résumé
We isolated major histocompatibility complex class II B (MHCIIB) genes in the Barn owl (Tyto alba). A PCR-based approach combined with primer walking on genomic and complementary DNA as well as Southern blot analyses revealed the presence of two MHCIIB genes, both being expressed in spleen, liver, and blood. Characteristic structural features of MHCIIB genes as well as their expression and high non-synonymous substitution rates in the region involved in antigen binding suggest that both genes are functional. MHC organization in the Barn owl is simple compared to passerine species that show multiple duplications, and resembles the minimal essential MHC of chicken.
Mots-clé
Amino Acid Sequence, Animals, Evolution, Molecular, Histocompatibility Antigens Class II/genetics, Molecular Sequence Data, Strigiformes/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/05/2008 14:06
Dernière modification de la notice
14/02/2022 7:56
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