HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

Détails

ID Serval
serval:BIB_8E3742B0C835
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
Périodique
Nature
Auteur(s)
Rosa A., Chande A., Ziglio S., De Sanctis V., Bertorelli R., Goh S. L., McCauley S. M., Nowosielska A., Antonarakis S. E., Luban J., Santoni F. A., Pizzato M.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
2015
Volume
526
Numéro
7572
Pages
212-7
Langue
anglais
Notes
Rosa, Annachiara
Chande, Ajit
Ziglio, Serena
De Sanctis, Veronica
Bertorelli, Roberto
Goh, Shih Lin
McCauley, Sean M
Nowosielska, Anetta
Antonarakis, Stylianos E
Luban, Jeremy
Santoni, Federico Andrea
Pizzato, Massimo
eng
249968/European Research Council/International
DP1 DA034990/DA/NIDA NIH HHS/
DP1DA034990/DA/NIDA NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
England
Nature. 2015 Oct 8;526(7572):212-7. doi: 10.1038/nature15399. Epub 2015 Sep 30.
Résumé
HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell-dependent manner. Here we identify the host transmembrane protein SERINC5, and to a lesser extent SERINC3, as a potent inhibitor of HIV-1 particle infectivity that is counteracted by Nef. SERINC5 localizes to the plasma membrane, where it is efficiently incorporated into budding HIV-1 virions and impairs subsequent virion penetration of susceptible target cells. Nef redirects SERINC5 to a Rab7-positive endosomal compartment and thereby excludes it from HIV-1 particles. The ability to counteract SERINC5 was conserved in Nef encoded by diverse primate immunodeficiency viruses, as well as in the structurally unrelated glycosylated Gag from murine leukaemia virus. These examples of functional conservation and convergent evolution emphasize the fundamental importance of SERINC5 as a potent anti-retroviral factor.
Mots-clé
Animals, Cell Line, Cell Membrane/metabolism/virology, Endosomes/chemistry/metabolism, Evolution, Molecular, Gene Products, gag/metabolism, Gene Products, nef/chemistry/metabolism, HIV-1/chemistry/*physiology, Host Specificity, *Host-Pathogen Interactions, Humans, Leukemia Virus, Murine/chemistry/physiology, Membrane Proteins/analysis/*antagonists & inhibitors/*metabolism, Neoplasm Proteins/metabolism, Primates/virology, Receptors, Cell Surface/metabolism, Virion/*chemistry/*metabolism, nef Gene Products, Human Immunodeficiency Virus/*metabolism, rab GTP-Binding Proteins/metabolism
Pubmed
Création de la notice
20/05/2019 12:52
Dernière modification de la notice
02/10/2019 5:26
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