Computed tomography (CT) has influenced numerous fields since its inception in the 1970s. The field of palaeoanthropology significantly benefited from this efficient and non-invasive medium in terms of the conservation, reconstruction and analysis of fossil human remains. Over the past decade, there has been a steady increase in the number of forensic anthropological studies incorporating virtual osteological analyses. Because of the increasing importance of these modern cross-sectional imaging techniques and the requirement for standardized parameters in forensic science, we deemed it important to outline the history and development of CT applications in these related academic areas. The present paper outlines the history of “virtual anthropology” and osteological multi-detector CT in the context of palaeoanthropology and forensic anthropology.