Increased frequency of nonconventional double positive CD4CD8 alphabeta T cells in human breast pleural effusions.

Détails

Ressource 1Télécharger: BIB_8C9E478C625B.P001.pdf (237.60 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_8C9E478C625B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Increased frequency of nonconventional double positive CD4CD8 alphabeta T cells in human breast pleural effusions.
Périodique
International Journal of Cancer
Auteur(s)
Desfrançois J., Derré L., Corvaisier M., Le Mével B., Catros V., Jotereau F., Gervois N.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Statut éditorial
Publié
Date de publication
2009
Volume
125
Numéro
2
Pages
374-380
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Breast cancer remains a leading cause of cancer-related death within the female population. Immunotherapy is expected to provide additional therapeutic benefits but has met so far limited success. This may be due in part to the poor understanding of immune responses to breast cancer. Although CD4(+) and CD8(+) T lymphocytes infiltrate these tumors, the phenotype and functions of these cells remain ill defined. This study was designed to investigate further about these questions, taking advantage of multiparameter flow cytometry on lymphocytes derived from peripheral blood, solid tumors, metastatic lymph nodes and pleural effusions samples of patients with breast cancer. Results showed that, in addition to conventional CD4(+) and CD8(+) alphabeta T cells, individual tumors and most pleural effusions contained significant fractions of unconventional double positive (DP) CD4(+)CD8(+) alphabeta T cells. These DP T cells displayed the phenotype and cytotoxic potential of effector/memory activated CD8(+) T cells but differed essentially from these cells by a high production of IL-5 and IL-13. The increased frequency of DP T cells in advanced breast cancer and their high lytic potential and original cytokine profile suggest that this T-cell subset may play a specific role in the regulation of immune responses to human breast cancer.
Mots-clé
Breast Neoplasms/immunology, Breast Neoplasms/pathology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Female, Flow Cytometry, Humans, Neoplasm Metastasis, Pleural Effusion/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/03/2014 10:00
Dernière modification de la notice
20/08/2019 14:50
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