Increased frequency of nonconventional double positive CD4CD8 alphabeta T cells in human breast pleural effusions.

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State: Public
Version: Final published version
Serval ID
serval:BIB_8C9E478C625B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Increased frequency of nonconventional double positive CD4CD8 alphabeta T cells in human breast pleural effusions.
Journal
International Journal of Cancer
Author(s)
Desfrançois J., Derré L., Corvaisier M., Le Mével B., Catros V., Jotereau F., Gervois N.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Publication state
Published
Issued date
2009
Volume
125
Number
2
Pages
374-380
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Breast cancer remains a leading cause of cancer-related death within the female population. Immunotherapy is expected to provide additional therapeutic benefits but has met so far limited success. This may be due in part to the poor understanding of immune responses to breast cancer. Although CD4(+) and CD8(+) T lymphocytes infiltrate these tumors, the phenotype and functions of these cells remain ill defined. This study was designed to investigate further about these questions, taking advantage of multiparameter flow cytometry on lymphocytes derived from peripheral blood, solid tumors, metastatic lymph nodes and pleural effusions samples of patients with breast cancer. Results showed that, in addition to conventional CD4(+) and CD8(+) alphabeta T cells, individual tumors and most pleural effusions contained significant fractions of unconventional double positive (DP) CD4(+)CD8(+) alphabeta T cells. These DP T cells displayed the phenotype and cytotoxic potential of effector/memory activated CD8(+) T cells but differed essentially from these cells by a high production of IL-5 and IL-13. The increased frequency of DP T cells in advanced breast cancer and their high lytic potential and original cytokine profile suggest that this T-cell subset may play a specific role in the regulation of immune responses to human breast cancer.
Keywords
Breast Neoplasms/immunology, Breast Neoplasms/pathology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Female, Flow Cytometry, Humans, Neoplasm Metastasis, Pleural Effusion/immunology
Pubmed
Web of science
Open Access
Yes
Create date
31/03/2014 11:00
Last modification date
20/08/2019 15:50
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