Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.

Détails

Ressource 1Télécharger: BIB_8C089A0C707E.P001.pdf (1918.23 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_8C089A0C707E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.
Périodique
Neuron
Auteur⸱e⸱s
Cabungcal J.H., Counotte D.S., Lewis E.M., Tejeda H.A., Piantadosi P., Pollock C., Calhoon G.G., Sullivan E.M., Presgraves E., Kil J., Hong L.E., Cuenod M., Do K.Q., O'Donnell P.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
83
Numéro
5
Pages
1073-1084
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Abnormal development can lead to deficits in adult brain function, a trajectory likely underlying adolescent-onset psychiatric conditions such as schizophrenia. Developmental manipulations yielding adult deficits in rodents provide an opportunity to explore mechanisms involved in a delayed emergence of anomalies driven by developmental alterations. Here we assessed whether oxidative stress during presymptomatic stages causes adult anomalies in rats with a neonatal ventral hippocampal lesion, a developmental rodent model useful for schizophrenia research. Juvenile and adolescent treatment with the antioxidant N-acetyl cysteine prevented the reduction of prefrontal parvalbumin interneuron activity observed in this model, as well as electrophysiological and behavioral deficits relevant to schizophrenia. Adolescent treatment with the glutathione peroxidase mimic ebselen also reversed behavioral deficits in this animal model. These findings suggest that presymptomatic oxidative stress yields abnormal adult brain function in a developmentally compromised brain, and highlight redox modulation as a potential target for early intervention.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/10/2014 17:24
Dernière modification de la notice
20/08/2019 14:50
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