Detection of immune danger signals by NALP3.

Détails

ID Serval
serval:BIB_8B6362D8B067
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Detection of immune danger signals by NALP3.
Périodique
Journal of Leukocyte Biology
Auteur(s)
Martinon F.
ISSN
0741-5400 (Print)
ISSN-L
0741-5400
Statut éditorial
Publié
Date de publication
2008
Volume
83
Numéro
3
Pages
507-511
Langue
anglais
Résumé
The innate immune system in animals has been forged to detect microbes, coordinate symbiotic responses, and mount immune defenses against pathogens. Recently, innate immunity was shown to detect signals released by damaged cells or tissues such as uric acid or ATP. These danger signals were proposed to be important in promoting and regulating inflammation upon trauma or pathogen insults. The physiological relevance of these signals in the immune response and their mechanisms of action are still unclear. Recent findings suggest that some danger signals activate the NALP3 inflammasome, an innate immune complex that controls inflammatory caspases and IL-1 activation.
Mots-clé
Adenosine Triphosphate/analysis, Animals, Biological Markers/analysis, Humans, Immunity, Innate, Inflammation/diagnosis, Inflammation/immunology, Irritants, Mammals, Models, Biological, Repressor Proteins/analysis, Skin Diseases/diagnosis, Skin Diseases/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/02/2011 16:36
Dernière modification de la notice
20/08/2019 15:50
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