Detection of immune danger signals by NALP3.

Details

Serval ID
serval:BIB_8B6362D8B067
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Detection of immune danger signals by NALP3.
Journal
Journal of Leukocyte Biology
Author(s)
Martinon F.
ISSN
0741-5400 (Print)
ISSN-L
0741-5400
Publication state
Published
Issued date
2008
Volume
83
Number
3
Pages
507-511
Language
english
Abstract
The innate immune system in animals has been forged to detect microbes, coordinate symbiotic responses, and mount immune defenses against pathogens. Recently, innate immunity was shown to detect signals released by damaged cells or tissues such as uric acid or ATP. These danger signals were proposed to be important in promoting and regulating inflammation upon trauma or pathogen insults. The physiological relevance of these signals in the immune response and their mechanisms of action are still unclear. Recent findings suggest that some danger signals activate the NALP3 inflammasome, an innate immune complex that controls inflammatory caspases and IL-1 activation.
Keywords
Adenosine Triphosphate/analysis, Animals, Biological Markers/analysis, Humans, Immunity, Innate, Inflammation/diagnosis, Inflammation/immunology, Irritants, Mammals, Models, Biological, Repressor Proteins/analysis, Skin Diseases/diagnosis, Skin Diseases/immunology
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2011 15:36
Last modification date
20/08/2019 14:50
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