Variability of response to methadone: genome-wide DNA methylation analysis in two independent cohorts.
Détails
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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_8A903190C0C4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Variability of response to methadone: genome-wide DNA methylation analysis in two independent cohorts.
Périodique
Epigenomics
ISSN
1750-192X (Electronic)
ISSN-L
1750-192X
Statut éditorial
Publié
Date de publication
02/2016
Peer-reviewed
Oui
Volume
8
Numéro
2
Pages
181-195
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Methadone maintenance treatment is characterized by large interindividual dose variability. The aim of this study was to evaluate whether DNA methylations are associated with daily dose of methadone.
Subjects stabilized at high (n = 12) or low (n = 12) methadone doses were selected from two independent cohorts (French and Swiss). DNA methylation patterns were analyzed using HumanMethylation450 BeadChips.
In total, 584 differentially methylated sites were identified in the French cohort corresponding to 352 genes. Of these, 26 were replicated in the Swiss cohort. The methylation status of 13 genes varied similarly in both cohorts and calcium signaling pathway was significantly enriched.
Our results indicate that differentially methylated sites are associated with methadone daily dose and give insights into the molecular pathways underlying this interindividual dose variability.
Subjects stabilized at high (n = 12) or low (n = 12) methadone doses were selected from two independent cohorts (French and Swiss). DNA methylation patterns were analyzed using HumanMethylation450 BeadChips.
In total, 584 differentially methylated sites were identified in the French cohort corresponding to 352 genes. Of these, 26 were replicated in the Swiss cohort. The methylation status of 13 genes varied similarly in both cohorts and calcium signaling pathway was significantly enriched.
Our results indicate that differentially methylated sites are associated with methadone daily dose and give insights into the molecular pathways underlying this interindividual dose variability.
Mots-clé
Analgesics, Opioid/administration & dosage, Analgesics, Opioid/pharmacology, Cluster Analysis, Cohort Studies, CpG Islands, DNA Methylation/drug effects, Female, Gene Expression Regulation, Genome, Human, Genome-Wide Association Study, High-Throughput Nucleotide Sequencing, Humans, Male, Methadone/administration & dosage, Methadone/pharmacology
Pubmed
Création de la notice
08/02/2016 11:24
Dernière modification de la notice
20/08/2019 15:49
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