c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_89FA771824D7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes.
Périodique
Frontiers in immunology
Auteur⸱e⸱s
Imbratta C., Hussein H., Andris F., Verdeil G.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
11
Pages
206
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors. Formerly introduced solely as a Th2 transcription factor, the role attributed to c-Maf has gradually broadened over the years and has extended to most, if not all, known immune cell types. The influence of c-Maf is particularly prominent among T cell subsets, where c-Maf regulates the differentiation as well as the function of multiple subsets of CD4 and CD8 T cells, lending it a crucial position in adaptive immunity and anti-tumoral responsiveness. Recent research has also revealed the role of c-Maf in controlling Th17 responses in the intestine, positioning it as an essential factor in intestinal homeostasis. This review aims to present and discuss the recent advances highlighting the particular role played by c-Maf in T lymphocyte differentiation, function, and homeostasis.
Mots-clé
T cells, c-Maf, gut, interleukin-10, tolerance
Pubmed
Open Access
Oui
Création de la notice
05/03/2020 15:30
Dernière modification de la notice
15/01/2021 7:10
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