c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes.

Details

Serval ID
serval:BIB_89FA771824D7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes.
Journal
Frontiers in immunology
Author(s)
Imbratta C., Hussein H., Andris F., Verdeil G.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
11
Pages
206
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors. Formerly introduced solely as a Th2 transcription factor, the role attributed to c-Maf has gradually broadened over the years and has extended to most, if not all, known immune cell types. The influence of c-Maf is particularly prominent among T cell subsets, where c-Maf regulates the differentiation as well as the function of multiple subsets of CD4 and CD8 T cells, lending it a crucial position in adaptive immunity and anti-tumoral responsiveness. Recent research has also revealed the role of c-Maf in controlling Th17 responses in the intestine, positioning it as an essential factor in intestinal homeostasis. This review aims to present and discuss the recent advances highlighting the particular role played by c-Maf in T lymphocyte differentiation, function, and homeostasis.
Keywords
T cells, c-Maf, gut, interleukin-10, tolerance
Pubmed
Open Access
Yes
Create date
05/03/2020 16:30
Last modification date
26/05/2020 6:26
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