Neuroendocrine neoplasms of the esophagus and stomach.

Détails

Ressource 1Télécharger: slarosa.pdf (1381.95 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_89ADB5FACC6A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Neuroendocrine neoplasms of the esophagus and stomach.
Périodique
Pathologica
Auteur(s)
Mastracci L., Rindi G., Grillo F., Solcia E., Campora M., Fassan M., Parente P., Vanoli A., La Rosa S.
ISSN
1591-951X (Electronic)
ISSN-L
0031-2983
Statut éditorial
Publié
Date de publication
02/2021
Peer-reviewed
Oui
Volume
113
Numéro
1
Pages
5-11
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Esophageal neuroendocrine neoplasms (E-NENs) are much rarer than other gastro-entero-pancreatic neuroendocrine neoplasms, the majority showing aggressive behavior with early dissemination and poor prognosis. Among E-NENs, exceptionally rare well differentiated neuroendocrine tumors (E-NET) and more frequent esophageal poorly differentiated neuroendocrine carcinomas (E-NEC) and mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN) can be recognized. E-NECs usually exhibit a small cell morphology or mixed small and large cells. Esophageal MiNEN are composed of NEC component admixed with adenocarcinoma or squamous cell carcinoma. Gastric (G) NENs encompass a wide spectrum of entities ranging from indolent G-NETs to highly aggressive G-NECs and MiNENs. Among G-NETs, ECL-cell NETs are the most common and, although composed of histamine-producing cells, are a heterogeneous group of neoplastic proliferations showing different clinical and prognostic features depending on the patient's clinico-pathological background including the morphology of the peri-tumoral mucosa, gastrin serum levels, presence or absence of antral G-cell hyperplasia, and presence or absence of MEN1 syndrome. In general, NET associated with hypergastrinemia show a better outcome than NET not associated with hypergastrinemia. G-NECs and MiNENs are aggressive neoplasms more frequently observed in males and associated with a dismal prognosis.
Mots-clé
MiNEN, esophagus, neuroendocrine carcinoma, neuroendocrine neoplasms, neuroendocrine tumor, stomach
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2021 13:12
Dernière modification de la notice
22/05/2021 5:34
Données d'usage