Neuroendocrine neoplasms of the esophagus and stomach.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_89ADB5FACC6A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neuroendocrine neoplasms of the esophagus and stomach.
Journal
Pathologica
Author(s)
Mastracci L., Rindi G., Grillo F., Solcia E., Campora M., Fassan M., Parente P., Vanoli A., La Rosa S.
ISSN
1591-951X (Electronic)
ISSN-L
0031-2983
Publication state
Published
Issued date
02/2021
Peer-reviewed
Oui
Volume
113
Number
1
Pages
5-11
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Esophageal neuroendocrine neoplasms (E-NENs) are much rarer than other gastro-entero-pancreatic neuroendocrine neoplasms, the majority showing aggressive behavior with early dissemination and poor prognosis. Among E-NENs, exceptionally rare well differentiated neuroendocrine tumors (E-NET) and more frequent esophageal poorly differentiated neuroendocrine carcinomas (E-NEC) and mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN) can be recognized. E-NECs usually exhibit a small cell morphology or mixed small and large cells. Esophageal MiNEN are composed of NEC component admixed with adenocarcinoma or squamous cell carcinoma. Gastric (G) NENs encompass a wide spectrum of entities ranging from indolent G-NETs to highly aggressive G-NECs and MiNENs. Among G-NETs, ECL-cell NETs are the most common and, although composed of histamine-producing cells, are a heterogeneous group of neoplastic proliferations showing different clinical and prognostic features depending on the patient's clinico-pathological background including the morphology of the peri-tumoral mucosa, gastrin serum levels, presence or absence of antral G-cell hyperplasia, and presence or absence of MEN1 syndrome. In general, NET associated with hypergastrinemia show a better outcome than NET not associated with hypergastrinemia. G-NECs and MiNENs are aggressive neoplasms more frequently observed in males and associated with a dismal prognosis.
Keywords
MiNEN, esophagus, neuroendocrine carcinoma, neuroendocrine neoplasms, neuroendocrine tumor, stomach
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2021 13:12
Last modification date
22/05/2021 5:34
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