Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort.

Détails

ID Serval
serval:BIB_895023AD89B5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort.
Périodique
Diabetes & metabolism
Auteur(s)
Fumeron F., Nicolas A., Bastard J.P., Fellahi S., Wigger L., Ibberson M., Cruciani-Guglielmacci C., Le Stunff H., Velho G., Magnan C., Marre M., Balkau B., Roussel R.
ISSN
1878-1780 (Electronic)
ISSN-L
1262-3636
Statut éditorial
Publié
Date de publication
04/2020
Peer-reviewed
Oui
Volume
46
Numéro
2
Pages
144-149
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In the D.E.S.I.R. cohort, higher consumption of dairy products was associated with lower incidence of hyperglycaemia, and dihydroceramide concentrations were higher in those who progressed to diabetes. Our aim here was to study the relationships between dairy consumption and concentrations of dihydroceramides and ceramides.
In the D.E.S.I.R. cohort, men and women aged 30-65 years, volunteers from West-Central France, were included in a 9-year follow-up with examinations every 3 years, including food-frequency questionnaires. Two items concerned dairy products (cheese, other dairy products except cheese). At each examination, dihydroceramides and ceramides were determined by mass spectrometry in a cohort subset; in the present study, the 105 people who did not progress to type 2 diabetes were analyzed, as the disorder per se might be a confounding factor.
Higher consumption of dairy products (except cheese) was associated with total plasma dihydroceramides during the follow-up, but only in women (P=0.01 for gender interaction). In fact, dihydroceramide levels were lower in women with high vs low consumption (P=0.03), and were significantly increased during follow-up (P=0.01) in low consumers only. There was also a trend for lower ceramides in women with high dairy (except cheese) intakes (P=0.08). Cheese was associated with dihydroceramide and ceramide changes during follow-up (P=0.04 for both), but no clear trend was evident in either low or high consumers.
These results show that, in women, there is an inverse association between fresh dairy product consumption and predictive markers (dihydroceramides) of type 2 diabetes.
Mots-clé
Ceramides, Dairy product intake, Dihydroceramides, General population, Longitudinal study
Pubmed
Web of science
Création de la notice
24/06/2019 16:23
Dernière modification de la notice
13/06/2020 5:20
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