Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal.

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_883A361B1C44
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal.
Périodique
Neurosurgical Focus
Auteur⸱e⸱s
Messerer M., De Battista J.C., Raverot G., Kassis S., Dubourg J., Lapras V., Trouillas J., Perrin G., Jouanneau E.
ISSN
1092-0684 (Electronic)
ISSN-L
1092-0684
Statut éditorial
Publié
Date de publication
2011
Volume
30
Numéro
4
Pages
E11
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
OBJECT: Because of their size and lateral extension, total removal of nonfunctioning pituitary adenomas (NFPAs) remains a challenge and postoperative tumor remnants are frequent. Endoscopy has improved the surgeon's view; however, its superiority in terms of surgical outcome remains undetermined. The authors' aim in this study was to compare the clinical results and morbidity between microscopic and endoscopic techniques in 164 patients with NFPAs.
METHODS: Tumoral (3D MR imaging), endocrinological, and ophthalmological results and morbidity were compared between 2 groups of 82 patients with newly diagnosed NFPAs surgically treated via either a sublabial microscopic approach (Group B) or a fully endonasal endoscopic technique (Group A).
RESULTS: The groups showed no difference in terms of clinical features, tumor size, or cavernous sinus invasion (p > 0.05). One year postoperatively, the quality of resection was significantly improved in Group A (gross-total removal [GTR]: 74% vs 50% in Group B, p = 0.002) with greater control of lateral extension (Knosp Grade 2: GTR 88.2% vs 47.8% in Group B, p = 0.02; Knosp Grade 3: 67.9% vs 16.7% in Group B, p < 0.001) and suprasellar extension (tumor height 20-30 mm: GTR 76% vs 53% in Group B, p = 0.01). Endocrinological outcome in patients with a partial deficiency in anterior pituitary function preoperatively was significantly better in Group A (improvement 56% vs 25% in Group B, stabilization 22% vs 46%, and aggravation 22% vs 29%; p = 0.01). Among the ophthalmologically symptomatic patients, 100% from Group A improved compared with 93% in Group B (p = 0.35). Lastly, no significant difference was found regarding morbidity. These data were supported by the literature in which the GTR rate is consistently higher for endoscopy compared with microscopy.
CONCLUSIONS: In this large series of patients with NFPAs, endoscopy improved the quality of resection and endocrinological outcome. Larger studies focusing on the impact of these promising results on the long-term recurrence of NFPAs are warranted.
Mots-clé
Adenoma/epidemiology, Adenoma/surgery, Adult, Aged, Aged, 80 and over, Endoscopy/methods, Female, Humans, Imaging, Three-Dimensional/methods, Longitudinal Studies, Magnetic Resonance Imaging/methods, Male, Microscopy/methods, Middle Aged, Neoplasm Recurrence, Local/etiology, Neurosurgical Procedures/methods, Ophthalmology, Pituitary Hormones/metabolism, Pituitary Neoplasms/epidemiology, Pituitary Neoplasms/surgery, Postoperative Complications/physiopathology, Retrospective Studies, Statistics, Nonparametric, Treatment Outcome, Young Adult
Pubmed
Web of science
Création de la notice
03/01/2014 18:55
Dernière modification de la notice
20/08/2019 14:47
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