Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil.

Détails

ID Serval
serval:BIB_8769E5A43DC1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil.
Périodique
Pharmacogenomics Journal
Auteur(s)
Dauvilliers Y., Neidhart E., Billiard M., Tafti M.
ISSN
1470-269X[print], 1470-269X[linking]
Statut éditorial
Publié
Date de publication
2002
Volume
2
Numéro
1
Pages
65-68
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The gene for catechol-O-methyltransferase (COMT) plays a key modulatory role in dopaminergic and noradrenergic neurotransmission. Recent evidence suggests that modafinil, like other stimulants, might act through the dopaminergic system. We have reported a sexual dimorphism and a strong effect of the COMT genotype on narcolepsy symptoms and hypothesized that response to modafinil treatment may be associated with the COMT genotype. Here we confirm that COMT genotype distribution between men and women narcoleptics is associated with response to modafinil. In addition, the optimal daily dose of modafinil is approximately 100 mg lower in women narcoleptics and lower in all narcoleptics with low activity COMT genotype. Our results suggest that a sexual dimorphism in COMT activity affects the response to modafinil and probably to other dopaminergic stimulants.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Benzhydryl Compounds/therapeutic use, Catechol O-Methyltransferase/genetics, Central Nervous System Stimulants/therapeutic use, Female, Genotype, Humans, Male, Middle Aged, Narcolepsy/drug therapy, Narcolepsy/enzymology, Sex Characteristics
Pubmed
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 14:46
Données d'usage