Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil.

Details

Serval ID
serval:BIB_8769E5A43DC1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil.
Journal
Pharmacogenomics Journal
Author(s)
Dauvilliers Y., Neidhart E., Billiard M., Tafti M.
ISSN
1470-269X[print], 1470-269X[linking]
Publication state
Published
Issued date
2002
Volume
2
Number
1
Pages
65-68
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The gene for catechol-O-methyltransferase (COMT) plays a key modulatory role in dopaminergic and noradrenergic neurotransmission. Recent evidence suggests that modafinil, like other stimulants, might act through the dopaminergic system. We have reported a sexual dimorphism and a strong effect of the COMT genotype on narcolepsy symptoms and hypothesized that response to modafinil treatment may be associated with the COMT genotype. Here we confirm that COMT genotype distribution between men and women narcoleptics is associated with response to modafinil. In addition, the optimal daily dose of modafinil is approximately 100 mg lower in women narcoleptics and lower in all narcoleptics with low activity COMT genotype. Our results suggest that a sexual dimorphism in COMT activity affects the response to modafinil and probably to other dopaminergic stimulants.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Benzhydryl Compounds/therapeutic use, Catechol O-Methyltransferase/genetics, Central Nervous System Stimulants/therapeutic use, Female, Genotype, Humans, Male, Middle Aged, Narcolepsy/drug therapy, Narcolepsy/enzymology, Sex Characteristics
Pubmed
Create date
24/01/2008 15:55
Last modification date
20/08/2019 14:46
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