Successful simultaneous islet-kidney transplantation using a steroid-free immunosuppression: two-year follow-up
Détails
ID Serval
serval:BIB_85F61B3EA690
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Successful simultaneous islet-kidney transplantation using a steroid-free immunosuppression: two-year follow-up
Périodique
American Journal of Transplantation
ISSN
1600-6135 (Print)
Statut éditorial
Publié
Date de publication
07/2004
Volume
4
Numéro
7
Pages
1117-23
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
We report on the feasibility of a glucocorticoid-free immunosuppression (sirolimus, low-dose tacrolimus, and daclizumab) in simultaneous islet-kidney transplantation in nine patients with type 1 diabetes. There was one renal primary nonfunction. Renal function (n = 8) as assessed by creatinine and creatinine clearance over time was 103 +/- 6 micromol/L and 64 +/- 6 mL/min/1.73 m(2), respectively. Five out of six patients with >or= 2 islet transplantations became insulin independent. The mean HbA(1c) during the follow-up period for all patients after transplantation is 6.2 +/- 0.9% as compared with 8.7 +/- 1.9% prior to transplant. These results in patients with a median follow-up of 2.3 years suggest that kidney transplantation under a glucocorticoid-free immunosuppression is feasible, and that the rate of insulin independence of 80% can be achieved not only in patients with no or minimal diabetes complications, but also in patients with more advanced late complications and in conjunction with kidney transplantation.
Mots-clé
Adult
Antibodies, Monoclonal/therapeutic use
Area Under Curve
C-Peptide/blood/chemistry
Creatinine/metabolism
Diabetes Complications
Female
Follow-Up Studies
Glucocorticoids/metabolism
Hemoglobins/metabolism
Humans
Immune Tolerance
Immunoglobulin G/therapeutic use
Immunosuppression
Immunosuppressive Agents/*pharmacology
Insulin/metabolism
Islets of Langerhans
Islets of Langerhans Transplantation/*methods
Kidney/metabolism/physiology
Kidney Transplantation/*methods
Male
Middle Aged
Pancreas/metabolism
Protein Conformation
Sirolimus/therapeutic use
Tacrolimus/therapeutic use
Time Factors
Tissue and Organ Procurement
Transplantation Conditioning
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 9:53
Dernière modification de la notice
20/08/2019 15:45