Successful simultaneous islet-kidney transplantation using a steroid-free immunosuppression: two-year follow-up

Details

Serval ID
serval:BIB_85F61B3EA690
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Successful simultaneous islet-kidney transplantation using a steroid-free immunosuppression: two-year follow-up
Journal
American Journal of Transplantation
Author(s)
Lehmann  R., Weber  M., Berthold  P., Zullig  R., Pfammatter  T., Moritz  W., Madler  K., Donath  M., Ambuhl  P., Demartines  N., Clavien And  P. A., Andreia Spinas  G.
ISSN
1600-6135 (Print)
Publication state
Published
Issued date
07/2004
Volume
4
Number
7
Pages
1117-23
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
We report on the feasibility of a glucocorticoid-free immunosuppression (sirolimus, low-dose tacrolimus, and daclizumab) in simultaneous islet-kidney transplantation in nine patients with type 1 diabetes. There was one renal primary nonfunction. Renal function (n = 8) as assessed by creatinine and creatinine clearance over time was 103 +/- 6 micromol/L and 64 +/- 6 mL/min/1.73 m(2), respectively. Five out of six patients with >or= 2 islet transplantations became insulin independent. The mean HbA(1c) during the follow-up period for all patients after transplantation is 6.2 +/- 0.9% as compared with 8.7 +/- 1.9% prior to transplant. These results in patients with a median follow-up of 2.3 years suggest that kidney transplantation under a glucocorticoid-free immunosuppression is feasible, and that the rate of insulin independence of 80% can be achieved not only in patients with no or minimal diabetes complications, but also in patients with more advanced late complications and in conjunction with kidney transplantation.
Keywords
Adult Antibodies, Monoclonal/therapeutic use Area Under Curve C-Peptide/blood/chemistry Creatinine/metabolism Diabetes Complications Female Follow-Up Studies Glucocorticoids/metabolism Hemoglobins/metabolism Humans Immune Tolerance Immunoglobulin G/therapeutic use Immunosuppression Immunosuppressive Agents/*pharmacology Insulin/metabolism Islets of Langerhans Islets of Langerhans Transplantation/*methods Kidney/metabolism/physiology Kidney Transplantation/*methods Male Middle Aged Pancreas/metabolism Protein Conformation Sirolimus/therapeutic use Tacrolimus/therapeutic use Time Factors Tissue and Organ Procurement Transplantation Conditioning
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 8:53
Last modification date
20/08/2019 14:45
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