T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.

Détails

Ressource 1Télécharger: BIB_83944FED4C41.P001.pdf (1047.69 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_83944FED4C41
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.
Périodique
Clinical and Developmental Immunology
Auteur(s)
Launois P., Drowart A., Bourreau E., Couppie P., Farber C.M., Van Vooren J.P., Huygen K.
ISSN
1740-2530 (Electronic)
ISSN-L
1740-2522
Statut éditorial
Publié
Date de publication
2011
Volume
2011
Pages
1-10
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.
Mots-clé
AIDS-Related Opportunistic Infections/immunology, AIDS-Related Opportunistic Infections/microbiology, Acyltransferases/immunology, Antigens, Bacterial/immunology, Belgium, French Guiana, HIV/physiology, HIV Infections/complications, HIV Infections/immunology, Humans, Immunologic Memory, Interferon-gamma/metabolism, Lymphocyte Activation/immunology, Mycobacterium Infections/complications, Mycobacterium Infections/immunology, Mycobacterium tuberculosis/immunology, T-Lymphocytes/immunology, Tuberculin Test, Tuberculosis/complications, Tuberculosis/immunology, Tuberculosis, Pulmonary/complications, Tuberculosis, Pulmonary/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/10/2011 15:02
Dernière modification de la notice
20/08/2019 15:43
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