T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.

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Serval ID
serval:BIB_83944FED4C41
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.
Journal
Clinical and Developmental Immunology
Author(s)
Launois P., Drowart A., Bourreau E., Couppie P., Farber C.M., Van Vooren J.P., Huygen K.
ISSN
1740-2530 (Electronic)
ISSN-L
1740-2522
Publication state
Published
Issued date
2011
Volume
2011
Pages
1-10
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.
Keywords
AIDS-Related Opportunistic Infections/immunology, AIDS-Related Opportunistic Infections/microbiology, Acyltransferases/immunology, Antigens, Bacterial/immunology, Belgium, French Guiana, HIV/physiology, HIV Infections/complications, HIV Infections/immunology, Humans, Immunologic Memory, Interferon-gamma/metabolism, Lymphocyte Activation/immunology, Mycobacterium Infections/complications, Mycobacterium Infections/immunology, Mycobacterium tuberculosis/immunology, T-Lymphocytes/immunology, Tuberculin Test, Tuberculosis/complications, Tuberculosis/immunology, Tuberculosis, Pulmonary/complications, Tuberculosis, Pulmonary/immunology
Pubmed
Web of science
Open Access
Yes
Create date
27/10/2011 14:02
Last modification date
20/08/2019 14:43
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