Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_832AED933B6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.
Périodique
Cell systems
Auteur(s)
Perez-Carrasco R., Barnes C.P., Schaerli Y., Isalan M., Briscoe J., Page K.M.
ISSN
2405-4712 (Print)
ISSN-L
2405-4712
Statut éditorial
Publié
Date de publication
25/04/2018
Peer-reviewed
Oui
Volume
6
Numéro
4
Pages
521-530.e3
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Although the structure of a genetically encoded regulatory circuit is an important determinant of its function, the relationship between circuit topology and the dynamical behaviors it can exhibit is not well understood. Here, we explore the range of behaviors available to the AC-DC circuit. This circuit consists of three genes connected as a combination of a toggle switch and a repressilator. Using dynamical systems theory, we show that the AC-DC circuit exhibits both oscillations and bistability within the same region of parameter space; this generates emergent behaviors not available to either the toggle switch or the repressilator alone. The AC-DC circuit can switch on oscillations via two distinct mechanisms, one of which induces coherence into ensembles of oscillators. In addition, we show that in the presence of noise, the AC-DC circuit can behave as an excitable system capable of spatial signal propagation or coherence resonance. Together, these results demonstrate how combinations of simple motifs can exhibit multiple complex behaviors.
Mots-clé
Gene Regulatory Networks, Models, Genetic, Models, Theoretical, Systems Theory, coherence, coherence resonance, dynamical systems, excitable systems, gene regulatory networks, multifunctional circuits, multistability, oscillations, synthetic biology
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/03/2018 19:00
Dernière modification de la notice
04/10/2019 6:08
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