Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.

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Serval ID
serval:BIB_832AED933B6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.
Journal
Cell systems
Author(s)
Perez-Carrasco R., Barnes C.P., Schaerli Y., Isalan M., Briscoe J., Page K.M.
ISSN
2405-4712 (Print)
ISSN-L
2405-4712
Publication state
Published
Issued date
25/04/2018
Peer-reviewed
Oui
Volume
6
Number
4
Pages
521-530.e3
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Although the structure of a genetically encoded regulatory circuit is an important determinant of its function, the relationship between circuit topology and the dynamical behaviors it can exhibit is not well understood. Here, we explore the range of behaviors available to the AC-DC circuit. This circuit consists of three genes connected as a combination of a toggle switch and a repressilator. Using dynamical systems theory, we show that the AC-DC circuit exhibits both oscillations and bistability within the same region of parameter space; this generates emergent behaviors not available to either the toggle switch or the repressilator alone. The AC-DC circuit can switch on oscillations via two distinct mechanisms, one of which induces coherence into ensembles of oscillators. In addition, we show that in the presence of noise, the AC-DC circuit can behave as an excitable system capable of spatial signal propagation or coherence resonance. Together, these results demonstrate how combinations of simple motifs can exhibit multiple complex behaviors.
Keywords
Gene Regulatory Networks, Models, Genetic, Models, Theoretical, Systems Theory, coherence, coherence resonance, dynamical systems, excitable systems, gene regulatory networks, multifunctional circuits, multistability, oscillations, synthetic biology
Pubmed
Web of science
Open Access
Yes
Create date
29/03/2018 19:00
Last modification date
04/10/2019 6:08
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