Small intestine without mucosa as a growing vascular conduit: a porcine experimental study
Détails
ID Serval
serval:BIB_823DDB52DBAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Small intestine without mucosa as a growing vascular conduit: a porcine experimental study
Périodique
Journal of Thoracic and Cardiovascular Surgery
ISSN
0022-5223
Statut éditorial
Publié
Date de publication
12/2002
Peer-reviewed
Oui
Volume
124
Numéro
6
Pages
1165-75
Notes
Journal Article --- Old month value: Dec
Résumé
OBJECTIVE: This study was conducted to check the feasibility of using small intestine without mucosa as a growing vascular conduit. METHOD: Autologous proximal jejunum without mucosa after treatment with heparin bonding was used as a free inferior vena cava interpositional graft between the renal veins and bifurcation of inferior vena cava in 8 piglets. Intravenous ultrasonography was performed at 1 to 3 months after the operation and at autopsy. RESULTS: One intraoperative death was related to anesthesia. At a mean follow-up of 80 days for the 7 surviving pigs, the weight had increased by 201%, from a mean of 32 kg to a mean of 94 kg. The grafts had increased in length by 128%, from a mean of 2.3 cm at implantation to a mean of 5.1 cm (P <.018) at explantation. In 6 animals the diameter of the graft was equal to that of the adjacent inferior vena cava. At postmortem examination, 6 grafts were patent. The single blocked graft had been patent 1 month after surgery. One graft had extensive septae inside, 2 had minor septae, 2 had microscopic septae, and 2 had no septae at all. Normal appearing adventitia, fibrous tissue, and endothelium (factor VIII-related antigen positive) lined all the grafts. In all 7 grafts, scattered proliferating fibroblasts (MIB1 positive) were observed. CONCLUSIONS: Small intestine without mucosa remodels and acts like a live, growing, layered, endothelialized, nonthrombogenic (after re-endothelialization) vascular conduit in a growing pig. This graft material could have potential as a growing vascular conduit in children.
Mots-clé
Animals
*Blood Vessel Prosthesis
Follow-Up Studies
*Intestinal Mucosa
Jejunum/growth & development/*transplantation/ultrastructure
Swine
Time Factors
Vena Cava, Inferior/surgery
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/02/2008 15:17
Dernière modification de la notice
20/08/2019 15:42