Small intestine without mucosa as a growing vascular conduit: a porcine experimental study

Détails

ID Serval
serval:BIB_823DDB52DBAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Small intestine without mucosa as a growing vascular conduit: a porcine experimental study
Périodique
Journal of Thoracic and Cardiovascular Surgery
Auteur(s)
Tucker  O. P., Syburra  T., Augstburger  M., van Melle  G., Gebhard  S., Bosman  F., von Segesser  L. K.
ISSN
0022-5223
Statut éditorial
Publié
Date de publication
12/2002
Peer-reviewed
Oui
Volume
124
Numéro
6
Pages
1165-75
Notes
Journal Article --- Old month value: Dec
Résumé
OBJECTIVE: This study was conducted to check the feasibility of using small intestine without mucosa as a growing vascular conduit. METHOD: Autologous proximal jejunum without mucosa after treatment with heparin bonding was used as a free inferior vena cava interpositional graft between the renal veins and bifurcation of inferior vena cava in 8 piglets. Intravenous ultrasonography was performed at 1 to 3 months after the operation and at autopsy. RESULTS: One intraoperative death was related to anesthesia. At a mean follow-up of 80 days for the 7 surviving pigs, the weight had increased by 201%, from a mean of 32 kg to a mean of 94 kg. The grafts had increased in length by 128%, from a mean of 2.3 cm at implantation to a mean of 5.1 cm (P <.018) at explantation. In 6 animals the diameter of the graft was equal to that of the adjacent inferior vena cava. At postmortem examination, 6 grafts were patent. The single blocked graft had been patent 1 month after surgery. One graft had extensive septae inside, 2 had minor septae, 2 had microscopic septae, and 2 had no septae at all. Normal appearing adventitia, fibrous tissue, and endothelium (factor VIII-related antigen positive) lined all the grafts. In all 7 grafts, scattered proliferating fibroblasts (MIB1 positive) were observed. CONCLUSIONS: Small intestine without mucosa remodels and acts like a live, growing, layered, endothelialized, nonthrombogenic (after re-endothelialization) vascular conduit in a growing pig. This graft material could have potential as a growing vascular conduit in children.
Mots-clé
Animals *Blood Vessel Prosthesis Follow-Up Studies *Intestinal Mucosa Jejunum/growth & development/*transplantation/ultrastructure Swine Time Factors Vena Cava, Inferior/surgery
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/02/2008 15:17
Dernière modification de la notice
08/05/2019 21:12
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