The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic

Détails

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ID Serval
serval:BIB_8121A0C54BC1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
UNIL/CHUV
Titre
The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic
Périodique
Journal of Clinical Microbiology
Auteur⸱e⸱s
Mueller  I., Betuela  I., Ginny  M., Reeder  J. C., Genton  B.
ISSN
0095-1137 (Print)
Statut éditorial
Publié
Date de publication
02/2007
Volume
45
Numéro
2
Pages
627-30
Notes
Clinical Trial
Journal Article --- Old month value: Feb
Résumé
Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P. falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common.
Mots-clé
Animals Antimalarials/therapeutic use Endemic Diseases Humans L-Lactate Dehydrogenase/*blood Malaria, Falciparum/diagnosis/*drug therapy/parasitology Malaria, Vivax/drug therapy/parasitology Papua New Guinea Parasitemia/diagnosis/*drug therapy/parasitology Parasitology/methods Plasmodium falciparum/drug effects/enzymology/*growth & development/isolation & purification *Reagent Kits, Diagnostic Sensitivity and Specificity Time Factors Treatment Outcome
OAI-PMH
oai:serval.unil.ch:BIB_8121A0C54BC1
DOI
10.1128/jcm.00816-06
Pubmed
17135432
Web of science
000244270000065
Open Access
Oui
Création de la notice
28/01/2008 12:49
Dernière modification de la notice
20/08/2019 15:41
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