The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic

Details

Serval ID
serval:BIB_8121A0C54BC1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic
Journal
Journal of Clinical Microbiology
Author(s)
Mueller  I., Betuela  I., Ginny  M., Reeder  J. C., Genton  B.
ISSN
0095-1137 (Print)
Publication state
Published
Issued date
02/2007
Volume
45
Number
2
Pages
627-30
Notes
Clinical Trial
Journal Article --- Old month value: Feb
Abstract
Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P. falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common.
Keywords
Animals Antimalarials/therapeutic use Endemic Diseases Humans L-Lactate Dehydrogenase/*blood Malaria, Falciparum/diagnosis/*drug therapy/parasitology Malaria, Vivax/drug therapy/parasitology Papua New Guinea Parasitemia/diagnosis/*drug therapy/parasitology Parasitology/methods Plasmodium falciparum/drug effects/enzymology/*growth & development/isolation & purification *Reagent Kits, Diagnostic Sensitivity and Specificity Time Factors Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:49
Last modification date
20/08/2019 14:41
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