Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis.
Détails
ID Serval
serval:BIB_8107581D288D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis.
Périodique
Journal of Cystic Fibrosis
ISSN
1873-5010 (Electronic)
ISSN-L
1569-1993
Statut éditorial
Publié
Date de publication
2012
Volume
11
Numéro
5
Pages
433-439
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
BACKGROUND: The role of respiratory viruses in cystic fibrosis (CF) exacerbations is incompletely understood.
METHODS: Cross-sectional study of CF children with a pulmonary exacerbation. Mid-turbinate swabs were tested by a direct immunofluorescent antibody assay and a multiplex PCR panel (ResPlex II v2.0, Qiagen). Resplex II was also applied to sputum or throat swab samples. Pulmonary function tests and quality of life and severity scores were recorded. Sputum cell counts, bacterial density and cytokines were measured.
RESULTS: 26/43 (60.5%) subjects tested positive for at least one respiratory virus by any diagnostic method applied to any sample type. Virus-positive patients were younger (p=0.047), more likely to be male (p=0.029), and had higher CF clinical severity (p=0.041) and lower quality of life (physical) scores (p=0.023) but similar IL-8, neutrophil percentage and elastase levels.
CONCLUSIONS: Compared to non-viral exacerbations, viral-related exacerbations were associated with worse severity and quality of life scores but similar pulmonary inflammation.
METHODS: Cross-sectional study of CF children with a pulmonary exacerbation. Mid-turbinate swabs were tested by a direct immunofluorescent antibody assay and a multiplex PCR panel (ResPlex II v2.0, Qiagen). Resplex II was also applied to sputum or throat swab samples. Pulmonary function tests and quality of life and severity scores were recorded. Sputum cell counts, bacterial density and cytokines were measured.
RESULTS: 26/43 (60.5%) subjects tested positive for at least one respiratory virus by any diagnostic method applied to any sample type. Virus-positive patients were younger (p=0.047), more likely to be male (p=0.029), and had higher CF clinical severity (p=0.041) and lower quality of life (physical) scores (p=0.023) but similar IL-8, neutrophil percentage and elastase levels.
CONCLUSIONS: Compared to non-viral exacerbations, viral-related exacerbations were associated with worse severity and quality of life scores but similar pulmonary inflammation.
Mots-clé
Adolescent, Age Factors, Bacteria/classification, Bacteria/isolation & purification, Bacterial Infections/diagnosis, Bacterial Infections/epidemiology, Canada/epidemiology, Child, Child, Preschool, Coinfection/epidemiology, Cross-Sectional Studies, Cystic Fibrosis/epidemiology, Cystic Fibrosis/physiopathology, Female, Humans, Male, Pharynx/microbiology, Prevalence, Quality of Life, Respiratory Function Tests, Respiratory Tract Infections/epidemiology, Respiratory Tract Infections/physiopathology, Severity of Illness Index, Sex Factors, Virus Diseases/diagnosis, Virus Diseases/epidemiology, Viruses/classification, Viruses/isolation & purification
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/06/2014 12:05
Dernière modification de la notice
20/08/2019 15:41
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