ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.
Détails
Télécharger: 32154289_BIB_80B5347CC572.pdf (514.46 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_80B5347CC572
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.
Périodique
ERJ open research
ISSN
2312-0541 (Print)
ISSN-L
2312-0541
Statut éditorial
Publié
Date de publication
01/2020
Peer-reviewed
Oui
Volume
6
Numéro
1
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/04/2022 16:54
Dernière modification de la notice
23/11/2022 8:12