ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.

Details

Serval ID
serval:BIB_80B5347CC572
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.
Journal
ERJ open research
Author(s)
Ubags N.D., Baker J., Boots A., Costa R., El-Merhie N., Fabre A., Faiz A., Heijink I.H., Hiemstra P.S., Lehmann M., Meiners S., Rolandsson Enes S., Bartel S.
ISSN
2312-0541 (Print)
ISSN-L
2312-0541
Publication state
Published
Issued date
01/2020
Peer-reviewed
Oui
Volume
6
Number
1
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine.
Pubmed
Web of science
Open Access
Yes
Create date
29/04/2022 16:54
Last modification date
30/04/2022 6:37
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