Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus.

Détails

Ressource 1Télécharger: BIB_7E8DF9B328A6.P001.pdf (630.16 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_7E8DF9B328A6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus.
Périodique
American Journal of Tropical Medicine and Hygiene
Auteur⸱e⸱s
Parmentier L., Cusini A., Müller N., Zangger H., Hartley M.A., Desponds C., Castiglioni P., Dubach P., Ronet C., Beverley S.M., Fasel N.
ISSN
1476-1645 (Electronic)
ISSN-L
0002-9637
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
94
Numéro
4
Pages
840-843
Langue
anglais
Notes
Publication types: Case Reports, pdf : case report
Résumé
Leishmania parasites cause a broad range of disease, with cutaneous afflictions being, by far, the most prevalent. Variations in disease severity and symptomatic spectrum are mostly associated to parasite species. One risk factor for the severity and emergence of leishmaniasis is immunosuppression, usually arising by coinfection of the patient with human immunodeficiency virus (HIV). Interestingly, several species of Leishmania have been shown to bear an endogenous cytoplasmic dsRNA virus (LRV) of the Totiviridae family, and recently we correlated the presence of LRV1 within Leishmania parasites to an exacerbation murine leishmaniasis and with an elevated frequency of drug treatment failures in humans. This raises the possibility of further exacerbation of leishmaniasis in the presence of both viruses, and here we report a case of cutaneous leishmaniasis caused by Leishmania braziliensis bearing LRV1 with aggressive pathogenesis in an HIV patient. LRV1 was isolated and partially sequenced from skin and nasal lesions. Genetic identity of both sequences reinforced the assumption that nasal parasites originate from primary skin lesions. Surprisingly, combined antiretroviral therapy did not impact the devolution of Leishmania infection. The Leishmania infection was successfully treated through administration of liposomal amphotericin B.
Mots-clé
Coinfection/parasitology, Coinfection/virology, Female, HIV Infections/complications, HIV Infections/parasitology, Humans, Leishmania braziliensis/virology, Leishmaniasis, Cutaneous/complications, Leishmaniasis, Cutaneous/pathology, Leishmaniavirus, Middle Aged, Skin/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/02/2016 17:22
Dernière modification de la notice
20/08/2019 14:39
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