Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_7DFCAAE42EAE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma.
Périodique
PloS one
Auteur⸱e⸱s
Mehra T., Grözinger G., Mann S., Guenova E., Moos R., Röcken M., Claussen C.D., Dummer R., Clasen S., Naumann A., Garbe C.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
11
Pages
e112535
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations.
116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages.
We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas.
Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p < 0.0001).
Mots-clé
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Melanoma/mortality, Melanoma/pathology, Middle Aged, Mucous Membrane/pathology, Prognosis, Survival Analysis, Survival Rate, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/08/2020 13:59
Dernière modification de la notice
23/11/2022 7:12
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