Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma.

Details

Serval ID
serval:BIB_7DFCAAE42EAE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma.
Journal
PloS one
Author(s)
Mehra T., Grözinger G., Mann S., Guenova E., Moos R., Röcken M., Claussen C.D., Dummer R., Clasen S., Naumann A., Garbe C.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
9
Number
11
Pages
e112535
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations.
116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages.
We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas.
Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p < 0.0001).
Keywords
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Melanoma/mortality, Melanoma/pathology, Middle Aged, Mucous Membrane/pathology, Prognosis, Survival Analysis, Survival Rate, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
27/08/2020 13:59
Last modification date
02/09/2020 5:26
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