The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse

Détails

ID Serval
serval:BIB_7DC913FBB3FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse
Périodique
Nature Genetics
Auteur(s)
Disteche  C. M., Brannan  C. I., Larsen  A., Adler  D. A., Schorderet  D. F., Gearing  D., Copeland  N. G., Jenkins  N. A., Park  L. S.
ISSN
1061-4036 (Print)
Statut éditorial
Publié
Date de publication
08/1992
Volume
1
Numéro
5
Pages
333-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
The gene encoding the granulocyte macrophage colony stimulating factor receptor alpha subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.
Mots-clé
Animals Chromosome Banding Chromosome Mapping Crosses, Genetic Female Granulocyte-Macrophage Colony-Stimulating Factor/*genetics Humans In Situ Hybridization Macromolecular Substances Male Mice Mice, Inbred C57BL Muridae Polymorphism, Restriction Fragment Length Telomere *X Chromosome
Pubmed
Web of science
Création de la notice
28/01/2008 13:58
Dernière modification de la notice
20/08/2019 15:39
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