The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse
Details
Serval ID
serval:BIB_7DC913FBB3FF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse
Journal
Nature Genetics
ISSN
1061-4036 (Print)
Publication state
Published
Issued date
08/1992
Volume
1
Number
5
Pages
333-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
The gene encoding the granulocyte macrophage colony stimulating factor receptor alpha subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.
Keywords
Animals
Chromosome Banding
Chromosome Mapping
Crosses, Genetic
Female
Granulocyte-Macrophage Colony-Stimulating Factor/*genetics
Humans
In Situ Hybridization
Macromolecular Substances
Male
Mice
Mice, Inbred C57BL
Muridae
Polymorphism, Restriction Fragment Length
Telomere
*X Chromosome
Pubmed
Web of science
Create date
28/01/2008 12:58
Last modification date
20/08/2019 14:39
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