Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.

Détails

Ressource 1Télécharger: fimmu-09-01927.pdf (1176.81 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_7A5968ADA94D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
Périodique
Frontiers in immunology
Auteur(s)
Juilland M., Thome M.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
9
Pages
1927
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
The scaffold proteins CARMA1-3 (encoded by the genes CARD11, -14 and -10) and CARD9 play major roles in signaling downstream of receptors with immunoreceptor tyrosine activation motifs (ITAMs), G-protein coupled receptors (GPCR) and receptor tyrosine kinases (RTK). These receptors trigger the formation of oligomeric CARMA/CARD-BCL10-MALT1 (CBM) complexes via kinases of the PKC family. The CBM in turn regulates gene expression by the activation of NF-κB and AP-1 transcription factors and controls transcript stability. The paracaspase MALT1 is the only CBM component having an enzymatic (proteolytic) activity and has therefore recently gained attention as a potential drug target. Here we review recent advances in the understanding of the molecular function of the protease MALT1 and summarize how MALT1 scaffold and protease function contribute to the transmission of CBM signals. Finally, we will highlight how dysregulation of MALT1 function can cause pathologies such as immunodeficiency, autoimmunity, psoriasis, and cancer.
Mots-clé
Autoimmune Diseases/immunology, Autoimmune Diseases/therapy, CARD Signaling Adaptor Proteins/immunology, Common Variable Immunodeficiency/immunology, Common Variable Immunodeficiency/pathology, Common Variable Immunodeficiency/therapy, Humans, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/immunology, NF-kappa B/immunology, Neoplasm Proteins/immunology, Neoplasms/immunology, Neoplasms/pathology, Neoplasms/therapy, Signal Transduction/immunology, Transcription Factor AP-1/immunology, BCR, EGFR, GPCR, RNA stability, TCR, Treg, paracaspase, ubiquitin
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/09/2018 7:43
Dernière modification de la notice
28/09/2019 5:08
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